Sildenafil and Nitrates: Viagra and Nitrates Don’t Mix

Sildenafil is a drug that is commonly used for treating Erectile Dysfunction (or ED, also known as impotence) and Pulmonary Arterial Hypertension (or PAH, a serious condition of the heart and lungs). Sildenafil works as a Phosphodiesterase 5 (or PDE5, an enzyme in the body) inhibitor, that relaxes the walls of the blood vessels in the body by reducing the pressure, allowing an improved rate of blood circulation. Sildenafil is commonly used for ED as it helps affected males attain a sustained and stronger erection by increasing the rate of blood flow to the penis.

The known drug brand for Sildenafil is Pfizer’s Viagra, the world’s first remedy for impotence. Pfizer has also specifically manufactured a Sildenafil drug brand for PAH and that is Revatio, which has smaller dosages compared to Viagra.

What is a Nitrate Drug?

Nitrates, on the other hand, are medications with the same work in the body. These drugs are mainly used for preventing and treating heart/chest pains which are caused by heart diseases.

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Nitrate Medications

It relieves the pains that a person with a heart disease experiences, especially the ones that has something to do with the arteries, Coronary Artery Disease for example.

What Are the Actions of Nitrates?

Nitrates work in the body similarly as how Sildenafil works. It is also referred to as a vasodilator drug, dilating the blood vessels and increasing their diameter, allowing the blood to flow more easily. Heart pain, (also known as Angina Pectoris) in patients with heart diseases is caused by the insufficient oxygen to the muscles of the heart due to inadequate blood flow.

Nitrates work by increasing the flow of blood and oxygen to the heart by expanding the arteries and veins in the body. The heart no longer has to work harder in pumping blood since the blood circulation in the body has been improved, the nitrates reducing the pressure in the arteries, easing the work of the heart muscles. As a result, it will relieve the body of Angina Pectoris and the patient will experience relief.

How Long After Nitroglycerin Can You Take Viagra?

The best time for taking Nitrate medicines after Viagra is 24 hours. This is to ensure that Viagra’s effects have already run its course so that the Nitrate’s effect won’t add up to Sildenafil which may cause Hypotension.

The US Food and Drug Administration themselves continuously issues warnings against using Sildenafil and Nitrates both at the same time. Both of these drugs are known to relax the muscles surrounding the blood vessels in the body, temporarily enlarging the veins and the capillaries where the blood flows and as a result, the blood pressure in the body decreases. When both of these medications are used together, the effects will be double, stacking the effect of one over the other. This will cause a very dangerous drop in the blood pressure to the point where the blood will have difficulty in circulating back to the heart, depriving it of oxygen and increasing the risk of a heart attack.

It is imperative for patients to consult their doctors first before deciding on using a medicine, especially when they have certain conditions in their health that should be carefully looked into. Patients who have heart diseases are not prohibited from taking Sildenafil for their ED but before they do, they should make sure that they have inquired for their physician’s advice concerning their nitrate medications, with specific instructions on when and when not to take them.

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Isosorbide Dinitrate Tablets

The mixture of these two drugs has already been proven fatal as there are already hundreds of Sildenafil-related deaths in America alone, patients who were unaware of the deadly mix of nitrates and Sildenafil and it was already too late for them to know. It is already a known fact that strenuous physical activity such as sex and exercise can cause heart attack to people with Angina Pectoris that’s why most patients are very careful. This additional information about the dangers of mixing Sildenafil with their medicines can save a lot of lives as many people are still unaware of this information.

List of Nitrate Drugs

Below are some of the common Nitrate brand names under their Nitrate categories. This list is very helpful especially for patients with heart diseases who do not have any information concerning the various types of Nitrate medications to avoid with Sildenafil and for Sildenafil users who want to know what the Nitrate brands are:

  1. Erthatyl Tetranitrate
  2. Pentaerythritol Tetranitrate
  3. Isosorbide Dinitrate
    • Dilatrate-SR
    • Isordil
    • Sorbitrate
  4. Sodium Nitroprusside
  5. Nitroglycerin
    • Nitrong
    • Transderm-Nitro
    • Nitrol ointment
    • Nitrostat
    • Nitro-time
    • Minitran
    • Nitrek
    • Nitrodisc
    • Nitrogard
    • Nitro-BID
    • Nitrolingual
    • Deponit
  6. Isosorbide Mononitrate
    • Monoket
    • Ismo
    • Imdur


Sildenafil and Nitrate medications are helpful drugs in their own respects. Both have the same functions of improving the blood circulation in the body by dilating the blood vessels, easing the blood pressure in the arteries and making the blood flow easily inside the body. Each has specific functions, one is for ED and the other is for heart disease. But as good as they are, these drugs should not go together as their combination causes a fatal effect on the body, lowering the blood pressure to the point of causing a heart attack. Customers should always consult their doctors and their healthcare providers before taking any drugs, just to make sure they are safe. if you are planning to shop for Sildenafil online, consider our TOP List of verified e-pharmacies.

It is one’s responsibility to look out after their own health. The doctors are only there to provide a proper diagnosis, appropriate medical attention and sound advice to patients seeking medical help. Maintaining good health is each one’s task and people should educate themselves concerning helpful information that can be used to preserve life.